Tag Archives: wrinkles

MitoQ

MitoQ Works Better When…

So you bought a bottle infused with this fancy molecule called MitoQ…  But will it work?

You want to get the best results possible, so prepare your skin to absorb this expensive stuff: Wash With Charcoal Powder

MitoQDon’t just wash and lightly scrub your skin with a towel before rubbing in charcoal-bulletproofthis expensive goo.  First use charcoal powder, to pull away dirt, oils, and dead skin that’s otherwise going to stand in the way between your live skin cells and the magic of MitoQ.

—Lightly scrub a capsule-full of coconut charcoal over your face, with just enough water involved to make the charcoal stick
—Let the damp charcoal sludge dry out.
—Wash with a towel and soapy, warm water.
—When the skin is dry, massage-in a generous blob of charcoal-powderthis fancy yellowish goo called “MitoQ”.

I figure it’s best to apply this stuff after a shower in the evening.  Then perhaps re-apply (without washing the skin again) right before bed.  Charcoal scrub >> shower >> MitoQ.

What is MitoQ?

Mitoq_structureHere’s a quick summary, from this article at joshmitteldorf.scienceblog.com

At the Second SENS conference in 2004, I sidled up to an expert whom I respected and asked, “What’s the optimal dose of CoQ10?”  He laughed and asked, in reply, “How much can you afford?”

But eating ubiquinone doesn’t work very well.  It is poorly absorbed in the digestive tract (the molecular variant called ubiquinol is supposed to mitigate this problem), little of it makes it into the blood stream, less into the cells, and a pittance to the mitochondria where it is needed.

…Targeting worked amazingly well, with virtually all of the Mito-Q molecules finding their way to the mitochondria. This means that very low doses can result in very high effectiveness.

Anything with a positive charge is drawn into the mitochondria, and if it’s not a proton, it won’t be pumped right back out again.  Murphy and Smith were inspired to create a molecule that combined ubiquinone at one end with a chemical tugboat at the other [this is MitoQ]…  The chemical “tugboat”, called TPP for tri-phenyl phosphonium, had been developed 25 years earlier in the Moscow State University lab of Vladimir Skulachev.

Skulachev, who had pioneered the early work on the right-hand part of the molecule, picked up this thread early on, and has sponsored much of the research that has demonstrated the rejuvenating potential of the molecule.  The molecular tugboat is known as a “Skulachev ion”, and a similar molecule to MitoQ has been dubbed “SkQ” and explored in Russian experiments.

Last year, a New Zealand company completed licensing requirements and created a manufacturing facility, and MitoQ is now available by order on the Internet for delivery worldwide.  The product was first announced at the A4M annual showcase meeting in November.  A year earlier, Skulachev’s company had begun to sell SkQ as eyedrops, available thus far only in Russia.  Skulachev’s group has long-term plans to develop the product for other uses as well, and to obtain licensing in Europe and America.

Skulachev is using a variant of the Mito-Q molecule based on plastoquinone rather than ubiquinone.  Plastoquinone is the equivalent of ubiquinone in green plants, and Skulachev reports that there is a wider range of effective dosage for plastoquinone compared to ubiquinone.  Scientists at MitoQ disagree that plastoquinone is better.

How can Whole Body Vibration possibly keep me looking younger?

More than aging skin, an “old face” is caused by bone erosion. The structure of your face changes as bone-density declines with age, and your skull structure basically erodes.

Whole body vibration increases bone density. Fact. That’s why USSR and USSA (formerly “USA”) astronauts have used WBV for decades now.

If increasing and maintaining bone density into old age, also prevents bone erosion, then WBV is a smart investment.the whole body vibrator

I’m no doctor, but this seems very reasonable. Cause-and-effect. But that’s a far-sighted goal to have, and not what motivates anyone to spend minutes every day standing on a vibration platform.

We do it because it feels freaking great.

Read more on the relationship between skin & bone structure